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Yeast Sir2 was first recognized as an H4 K16Ac deacetylase whereas mammalian SIRT1 is an H3 K9Ac or H4 K16Ac deacetylase. However it is now appreciated that sirtuins deacetylate not only histones but also many other transcriptional regulators and indeed their roles in aging extend far beyond heterochromatin including genome maintenance 33.
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The Texas mens basketball program began in 1906 under the direction of Scotland native Magnus Mainland a graduate engineering student and lineman for the Texas football team who organized coached and played on the Universitys first varsity basketball team.
. Mainland had been a nationally known basketball player as an undergraduate student at Wheaton College.
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